Bio-SurgTX: An Advanced Wound Care Product Alternative to Maggot Therapy and Conventional Methods Using Recombinant DNA Technology
del Valle, Rosalie
Maggot debridement therapy (MDT) is a cost-effective debridement method for chronic, intractable wounds. Despite studies showing its superiority over conventional therapies, its social and psychological perceptions of public abhorrence have greatly limited its use and acceptance by patients and health care professionals (Dossey, 2002). To overcome obstacles to MDT's acceptance, this study tested an innovative delivery system using a modified product from maggots' secretions containing the proteolytic enzymes responsible for accelerated wound healing to determine its efficacy and its potential to replace maggot therapy and existing conventional methods. In accordance with DNA research (Tachibana, Numata, & Goto, 2005), the genes encoding for proteolytic enzymes were isolated and the expressed proteins were purified and incorporated into a topical cream. Statistical analysis using MANOVA and results of testing of 750 patients with diabetic foot ulcers showed that the product's efficacy was comparable with MDT and more favorable than conventional therapies with higher acceptability.
Class / Instructor
BSC2421 Introduction to Biotechnology Honors / Gorgevska